Types of Antibiotics:

Concentration-dependent activity of antibiotics: Rate of kill is related to peak concentration above breakpoint,

eg: Aminoglycosides, fluoroquinolones, amphotericin B and metronidazole

Time-dependent activity: Kill rates related to the length of time concentrations are sustained above breakpoint MIC.

eg: Penicillins, cephalosporins, macrolides, carbapenems, clindamycin, linezolid and glycopeptides

MCQ 7:

All are active against anaerobes except:

a – Metronidazole

b – Clindamycin

c – Meropenem

d – Levofloxacin

Ans : Levofloxacin