Indications of Plasmapheresis:

1. Hyperviscosity syndromes (treatment of choice)

2. Myasthenic crisis

3. Hemolytic Uremic Syndrome / Thrombotic Thrombocytopenic Purpura

4. Guillain Barre Syndrome / Acute Inflammatory Demyelinating Polyneuropathy

5. Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome

6. Desensitization prior to transplantation by reducing the level of antidonor antibodies via plasmapheresis of blood has been useful in reducing the hazard of hyperacute rejection.

7. Post-transfusion Purpura

8. Pemphigus Vulgaris

9. Familial chylomicronemia syndrome (during pregnancy)

10. POEMS (polyneuropathy, organomegaly, endocrinopathy, M-proteins, and skin changes) syndrome