Concentration-dependent activity of antibiotics: Rate of kill is related to peak concentration above breakpoint,
eg: Aminoglycosides, fluoroquinolones, amphotericin B and metronidazole
Time-dependent activity: Kill rates related to the length of time concentrations are sustained above breakpoint MIC.eg: Penicillins, cephalosporins, macrolides, carbapenems, clindamycin, linezolid and glycopeptides
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